MyBioSource.com's IL12_2 Antibody (C-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, Flow Cytometry, Immunohistochemistry, and Western Blot. The IL12_2 Antibody (C-term) was generated using IL-12 R beta 2, and IL12RB2 as the antigen and it reacts with Human.
Description
The protein encoded by this gene is a type I transmembrane
protein identified as a subunit of the interleukin 12 receptor
complex. The coexpression of this and IL12RB1 proteins was shown to
lead to the formation of high-affinity IL12 binding sites and
reconstitution of IL12 dependent signaling. The expression of this
gene is up-regulated by interferon gamma in Th1 cells, and plays a
role in Th1 cell differentiation. The up-regulation of this gene is
found to be associated with a number of infectious diseases, such
as Crohn's disease and leprosy, which is thought to contribute to
the inflammatory response and host defense